Health Benefits And Uses Of L-Pyroglutamic Acid

Support for Brain Function

L-Pyroglutamic acid Background and Benefits

Pyroglutamic acid is a derivative of the amino acids glutamine and glutamic acid. It also known by other names such as pyroglutamate, 5-oxoproline and pidolic acid.

Pyroglutamic acid is a nonessential nutrient, meaning that the body normally biosynthesizes adequate quantities of pyroglutamic acid. It is typically formed in the body as a by-product of the glutathione cycle, in which the enzyme 5-oxoprolinase acts upon glutamic acid. Some pyroglutamic acid also forms when glutamine or glutamic acid spontaneously cyclizes. Pyroglutamic acid is available from a variety of dietary sources, including fruits and vegetables. Bacteriorhodopsin is one of the many proteins that contain pyroglutamic acid as a component.

Pyroglutamic acid has two specific forms known as enantiomers. These include D-pyroglutamic acid and L-pyroglutamic acid, with L-pyroglutamic acid being the biologically active enantiomer in humans. The primary biochemical use of L-pyroglutamic acid is believed to be increasing the activity of the neurotransmitter acetylcholine. It may also be used in the production of the neurotransmitters gamma-aminobutyric acid (GABA) and glycine.

Acetylcholine acts on both the central nervous system and peripheral nervous system. It is also the only neurotransmitter that affects the motor portion of the somatic nervous system. Furthermore, acetylcholine is the primary neurotransmitter for the autonomic ganglia.

Uses of L-Pyroglutamic Acid

The most common uses of L-pyroglutamic acid deal with brain function due to its role in supporting the healthy production of neurotransmitters. L-pyroglutamic acid is often used to support memory and learning in addition to managing anxiety.


Memory recall support

L-pyroglutamic acid may support both long-term and short-term memory recall. This effect relates to acetylcholine’s role in communication between brain cells.

Learning support

L-pyroglutamic acid may help to maintain communication between the two hemispheres of the brain. This benefit may help to support learning capability.

Anxiety management

Studies show that L-pyroglutamic acid may help to manage feelings of anxiety and stress. The results of this study also suggest that the specific mechanism of L-pyroglutamic acid is different from those of benzodiazepines.

Supports mental focus

L-pyroglutamic acid may also help weightlifters to maintain focus during intense workouts.

Signs You May Need L-Pyroglutamic Acid

Poor memory is one of the most common signs that you may need L-pyroglutamic acid. These tasks include both the retention of existing memories and formation of new memories. The loss of learning capabilities may also mean that you could benefit from supplements of L-pyroglutamic acid, especially for activities that combine logical and creative tasks. Additional signs that you may need L-pyroglutamic acid include high levels of stress and anxiety.

Synonyms and Similar Forms of L-Pyroglutamic Acid

L pyroglutamic acid, pyroglutamate, 5-oxoproline, pidolic acid


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