GG PURE

A natural supplement containing Geranylgeraniol (GG) specifically of interest to those who are on Statin drugs.
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was $65.95 $52.76 NZD (Incl Tax)
30 Day Supply | Size: 30 Capsules
30 Day Supply | Size: 30 Capsules

What is GG?

Geranylgeraniol (GG) is the raw fuel for some of our bodies most important processes. Very few people other than some scientists and well-informed Doctors are aware of this substance.

It plays a vital role in the mevalonate metabolic pathway– the series of chemical reactions in our bodies to support:

The deficiency of GG is dangerous

As we age, levels of GG in our bodies diminish, and this can be a factor in age-related conditions. This process is accelerated if you are taking a statin or one of the bisphosphonate medications.

This is because these medications cause ‘roadblocks’ in this mevalonate pathway. Statins are effective in lowering cholesterol because the ‘roadblock’ restricts the enzymes that the liver needs to produce cholesterol (note: 80% of the cholesterol in our bodies is produced by our livers, only 20% is from diet).

BUT… they also cut off the supply of the ‘fuel’ that our bodies need to produce GG, and this is serious because only a small portion of the GG that our bodies need can be obtained by diet. We are reliant on our own bodies to manufacture it.

When we are deficient in GG, all sorts of health issues may stem from it and is a major factor in the common side effects found by those people who are on statin medications. The side effects are primarily due to the reduction in Protein Prenylation that keeps the muscles healthy, and the lack of this process may lead to muscle pain.

The diagram below helps illustrate this:

  • This is a simplified diagram and is verified by many peer-reviewed research papers. References are made below.
  • The ‘'normal' illustrates the standard healthy 'pathway'. If you click on the 'statin' option, you can see what happens when you are on a statin. Not only is the production of cholesterol reduced, so is the production of GG with the flow-on effects to the other important functions.

The normal healthy metabolic pathway.

STATINS lower both cholesterol and GG with negative flow-on effects for four key processes.

Many scientists and health professionals are aware of the problems resulting from a GG deficiency in both ‘healthy’ aging people and those on medications, but there was no easy solution.

It has been well established by many researchers worldwide over many years in cellular experiments that taking GG exogenously (orally) would restore natural levels of GG in the body and negate the ill effects of its deficiency due to age or medications. The challenge was to find a suitable natural source of GG. GG is present in nature as part of some plants but only in small quantities.



Dr Barrie Tan – problem solver

Dr Barrie Tan, PhD  American Scientist and Researcher, solved the problem of how to replenish GG in the body naturally. Dr Tan is also a world expert on Vitamin E and Tocotrienols.

He has multiple PhD's and has spent his career travelling and searching out solutions to issues that affect the health of our bodies. He was a pioneer in the field of Vitamin E and Tocotrienol research and uncovered a lot of misconceptions in the area of Vitamin E, which everyone should be aware of.

He is the author of an enlightening and entertaining book called 'The Truth about Vitamin E', which we would urge everyone to read. We can provide you with a free copy by clicking here.



Dr Tan’s solution

After more than 10 years of research on GG, Vitamin E and Tocotrienols, Dr Tan perfected a technique of naturally extracting GG from the Annatto seeds harvested sustainably from the Amazon rain forest.

He was already very familiar with this plant after researching possible natural sources from the Amazon rain forest over many years. He developed the means of extracting Tocotrienols from the annatto seed and ultimately managed to perfect the technology to extract the GG as well... without the use of solvents or other chemicals.

This enabled us to produce the product GG PURE and make it available to our customers.

The below image illustrates the objective of GG PURE, which is to 'top up' and help support your GG at normal healthy levels.

NOTE: Because it is 'downstream' of the part of the pathway that statins use to inhibit the production of cholesterol, it has no negative impact on the efficacy of the statin medication.

A further explanation

Ivor Cummins, who is on our scientific board, recently interviewed Dr Barrie Tan to talk about GG. The video is quite technical but has a good explanation of how GG can benefit you.

Conclusion

If you are on either of the medications referred to, we would suggest that you talk to your Doctor about adding GG PURE to your regimen. It has no negative impact on your medications.

If you are free of medications but over 45 years of age, it would be a good idea to add it to your normal supplement regimen, even if you are taking Total Balance or any of our supplements. GG PURE is complimentary to all of them and has a different mechanism of action, and will support your overall health objectives.


Download our GG overview document

We have prepared a document for our customers who wish to dig deeper into the technicalities of this product or who wish to give a copy to their Doctor. Click on the image to download.

 

Scientific references

CAO, P. et al. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB Journal. Sep 2009;23(9)2844-2854.

JASKIEWICZ, A. et al. Geranylgeraniol Prevent Statin-Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy. Oxidative Medicine and Cellular Longevity Volume 2018, Article ID 6463807, 22 pages. 

JASKIEWICZ, A. et al. Diverse Action of Selected Statins on Skeletal Muscle Cells—An Attempt to Explain the Protective E_ect of Geranylgeraniol (GGOH) in Statin-Associated Myopathy (SAM). Journal of Clinical Medicine. 2019, 8, 694; doi:10.3390/jcm8050694.

CAMPIA, I. et al. Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. British Journal of Pharmacology. Dec 2009;158(7);1777-1786.

CORSINI, A. et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. Artherosclerosis. Jun 1993;101(11):117-125.

VOGT, A. et al. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. Oncogene Nov 7 1996;13(9):1991-1999.

CRICK, D. C. et al. Novel Salvage Pathway Utilizing Farnesol and Geranylgeraniol for Protein Isoprenylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 237, 483–487 (1997) ARTICLE NO. RC977145

KALEN, A. et al. Age-Related changes in the lipid compositions of rat and human tissues. Lipids, 1989; 24 (7) 579-584.

RRODICK, T. C. et al. Potential role of coenzyme Q10 in health and disease conditions. Nutrition and Dietary Supplements 2018:10 1–11

STOFFEL, W. et al. Synthese der K Vitamine and Ubichionone. Agnew Chem. 1960;72(17);627-627.

HIROTA, Y. et al. Functional Characterization of the Vitamin K2 Biosynthetic Enzyme UBIAD1. PLoS ONE 10(4): e0125737. doi:10.1371/journal.pone.0125737

OKUYAMA, H. et al. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology. 2015 8:2, 189-199, DOI: 10.1586/17512433.2015.1011125

HIROTA, Y. et al. Functional Characterization of the Vitamin K2 Biosynthetic Enzyme UBIAD1. PLoS ONE 10(4): e0125737. doi:10.1371/journal.pone.0125737

HARSHMAN, S.G. et al. Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice. Journal of Nutrition 2019;149(3);416-421.

OKAMURA, K. et al. Serum total and free testosterone level of Japanese men: a population-based study. International Journal of Urology (2005) 12, 810–814.

HO, H-J. et al. Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells. Bioscience, Biotechnology, and Biochemistry, 2016. Vol. 80, No. 4, 791–797

HO,H-J. et al. A novel function of geranylgeraniol in regulating testosterone production. Bioscience, Biotechnology, and Biochemistry, 2018 https://doi.org/10.1080/09168451.2017.1415129

Servings per bottle: 30
Daily serving: Adults - 1 capsule daily with food.

Take any time daily, with food.

Combines well with our Total Balance products.

If you are pregnant, lactating or taking any medications, please consult your health practitioner before starting new supplements.

If you have any questions, please contact us at customer.service@xtend-life.com

Supplement Facts

Serving size: 1 Capsule
Servings per container: 30
Amount Per Serving  
GG Gold®30 Annatto Extract
(30% Geranylgeraniol, 150mg)
500 mg*

Other ingredients: Modified Cornstarch, Capsule (Hydroxypropylmethyl Cellulose, Water).

If you are pregnant, lactating or taking any medications, please consult your health practitioner before starting new supplements.

L1512-1

What is GG?

Geranylgeraniol (GG) is a substance that is made in the human body via a biochemical pathway called the mevalonate pathway. This is the same biochemical pathway that makes cholesterol, CoQ10, dolichol and Heme A.

How is GG made?

GG is extracted from the Annatto plant (Bixa Orellana) using a clean (no solvents) extraction process.

How long will it take to feel the benefits of GG?

Difficult to say as it is a new product and most of the studies have been laboratory-based but it would be reasonable to expect to feel differences within three months.

Are there any side effects from taking GG?

There are no known side effects published in the literature.

Is it safe to take GG with my statin?

This was the main factor in developing this product. It should not affect the ability of your statin to lower cholesterol. However, you should always consult your doctor prior, if you are taking any medications.

Is it safe to take with other prescription medications, such as blood thinners?

While there is no evidence to suggest and adverse interactions with medications, you should consult your doctor prior to starting any new supplement, especially if you take blood thinners.

Should I continue taking CoQ10/is it safe to take GG with CoQ10?

We also recommend if customers wish to add our Omega 3 / QH Ultra to GG PURE.

What are the main benefits of GG?

GG is involved in numerous cellular functions, most notably is involved in muscle cell formation, muscle cell health and muscle cell structure. GG is also a building block of CoQ10. The main benefits are that it may assist with statin-induced muscle pain and/or weakness. Other benefits include supporting healthy testosterone levels and supporting healthy Vitamin K2 and Calcium deposition into bones and teeth.

What's Geranylgeranylpyrophosphate?

Geranylgeraniol (GG) is available in supplement form. When taken orally, this is converted to the active form in the body, which is called geranylgeranylpyrophosphate (GGPP).

Will GG help with cholesterol?

GG will not help with your cholesterol as it is downstream in the biochemical (mevalonate) pathway.

Can I take GG if I have a diagnosed heart condition?

Our view is a resounding yes. BUT, when you have any condition you should get your Doctors OK before commencing on any supplement regimen.

Can I take GG if I have stents?

There is no evidence to suggest taking GG would cause a problem for someone with stents. However, you should consult your doctor prior to starting GG.

Are these vegan, vegetarian, gluten-free?

Yes GG is derived from the Annatto plant. The capsule is derived from plant cellulose. 

Is it safe to take GG while pregnant?

If you are pregnant, please consult your doctor before taking GG.

Is it safe to take GG while breastfeeding?

If you are breastfeeding, please consult your doctor before taking GG.

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GG PURE

GG PURE

30 Day Supply | Size: 30 Capsules
30 Day Supply | Size: 30 Capsules

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